Exploring cognition in psychiatric disorders

People

Franziska Knolle. I am a junior group leader and former Marie Skłodowska-Curie Fellow at the Department of Neuroradiology, Klinikum rechts der Isar, Technichal University of Munich. I am using the framework of predictive processing to understanding mental disorders, especially psychosis. I am investigating how potentially dysfunctional predictive processing links to psychiatric symptoms. I am particularly interested in the interaction between subcortical and cortical regions. In my research, I am using computational and machine learning approaches on fMRI and MEG/EEG as well as behavioural data to explore these topics.

I completed my PhD at the Max Planck Institute of Cognitive and Brain Science, Leipzig, Germany, with Sonja Kotz and Erich Schroeger on subcortical contributions to predictive processing in the sensory domain. After taking a break from active science to complete my medical undergrad (Physikum) at the TU Dresden, Dresden, Germany, I took up a post-doc position with Jenny Morton on animal models for Huntington’s Disease at PDN, University of Cambridge, Cambridge, UK. I then proceeded to work with Graham Murray and Paul Fletcher (both Psychiatry, University of Cambridge, Cambridge, UK) on understanding dysfunctional mechanisms underlying psychotic symptoms, using fMRI and computational approaches.

Join the lab?

For prospective PhD students or PostDocs: Please get in contact for open positions. Also there are several great opportunities for funding (e.g., DFG, DAAD, Marie-Curie, Leopoldina, etc).

For Master students, HiWis, interns or summer students: Please get in contact directly (franziska.knolle at tum.de) to discuss opportunities.

Current Master and Doctoral Students

Clara Seifert. Clara is looking at neural circuits of novelty and emotional salience processing in early early psychosis and Parkinson’s psychosis. (Master Thesis)

Elisabeth Sterner. Elisabeth is investigating the neural and temporal signatures of the use of prior knowledge during language processing in individuals with high schizotypy and autism using EEG. (Master Thesis)

Madeleine Seitz. Madeleine is studying cognitive and brain alterations in adolescents scoring high for prodromal psychosis using machine learning algorithms. (Master Thesis)

Pritha Sen. Pritha is exploring two-stage decision making in OCD, applying computational modelling. Furthermore, she is investigating alterations in white matter tractography in early psychosis.

Sarah Daimer. In her successfully completed master’s project, she investigated the impact of the COVID-19 pandemic on mental health using machine learning approaches. She is further involved in mental health research in the lab.

Verena Demler. Verena is investigating the neural signatures of the use of prior knowledge during language processing in individuals with high schizotypy using fMRI and Magnetic Resonance Spectroscopy. (Medical Doctorate Thesis)

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Former summer students

Pritha Sen, NCP, LMU

Elisabeth Sterner, NCP, LMU

Omar Darawasha, Biomedical Engineering, TUM

Former master students

Jolina Mueller-Chorus, Psychology, LMU

Clara Sowade, Psychology, LMU

Collaborators

Dr Helen Blank (UKE Hamburg) – Prof Paul Fletcher (University of Cambridge) – Dr Olaf Hauk (MRC CBU) – Prof Sonja Kotz (Maastricht University) – Dr Lucy MacGregor (MRC CBU) – Dr Gemma Modinos (Kings College London) – Prof Jenny Morton (University of Cambridge) – Dr Graham Murray (University of Cambridge) – Dr Lisa Ronan (University of Cambridge) – Dr Christian Sorg (Technical University Munich) – Prof Roberto Viviani (University of Innsbruck)